Translational regulation in growth cones
نویسندگان
چکیده
منابع مشابه
RNA-binding proteins and translational regulation in axons and growth cones
RNA localization and regulation play an important role in the developing and adult nervous system. In navigating axons, extrinsic cues can elicit rapid local protein synthesis that mediates directional or morphological responses. The mRNA repertoire in axons is large and dynamically changing, yet studies suggest that only a subset of these mRNAs are translated after cue stimulation, suggesting ...
متن کاملActin dynamics in growth cones.
The mechanism of actin incorporation and turnover in the nerve growth cone was examined by immunoelectron microscopy and low-light-level video microscopy of cultured neurons injected with biotin-labeled actin or fluorescently labeled actin. We first determined the sites of actin incorporation into the cytoskeleton of growth cones by immunoelectron microscopy of cultured neurons injected with bi...
متن کاملMicrotubule organization in growth cones.
13. Albelda. S. M. & Huck. C. A. (1990) FASEH J. 4, 2868-2880 Kouslahti, E. (1001) J. Clin. Invest. 87. 1-’5 Hurridge. K., Fath, K., Kelly, T., Nuckolis, H. & Turner. C. (1988) Annu. Rev. Cell Hiol. 4, 487-525 Tamkun, J. W.. l)eSimone, I). W.. Fonda, I).? I’atel, K. S., Huck, C. A., Horwitz, A. F. & Hynes, K. 0. (1986) Cell (Cambridge. Mass.) 46,271-282 Springer, T. A. (1990) Nature (London) 34...
متن کاملTranslational regulation in development
Controlling gene expression by regulating translation allows a cell to respond to environmental cues more quickly than de novo transcription permits. Translation of mRNAs transcribed during early oogenesis has long been known to be repressed to permit accumulation of mRNAs for use later in development. In addition to providing such a stockpile of mRNAs, translational regulation has recently bee...
متن کاملTyrosine phosphorylation in early embryonic growth cones.
A large and growing body of evidence suggests that the regulation of tyrosine phosphorylation is important in the induction of axon growth. We have examined the subcellular distribution of enzymes regulating tyrosine phosphorylation in early embryonic brain, employing a preparation of isolated growth cone particles (GCPs). Because of the early developmental age and well-characterized nature of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2011
ISSN: 0959-437X
DOI: 10.1016/j.gde.2011.04.004